Abstract 68: Deferoxamine Preconditioning of Irradiated Tissue Increases Fat Graft Volume Retention

PURPOSE: Inflammatory breast cancer (IBC) is an aggressive disease characterized by the formation of tumor emboli, rapid local invasion, and lymphatic dissemination. Furthermore, IBC rapidly develops therapeutic resistance and evades immune surveillance and attack. For these reasons, the treatment of inflammatory breast cancer is extremely challenging and new therapeutic approaches are needed. Numerous studies have shown that adipose derived stem cells (ASCs), which are abundant in breast tissue, are recruited to the tumor microenvironment where they influence tumor progression. We have previously demonstrated the feasibility of using nanoparticles in conjunction with ASCs in treatmentresistant breast cancer. In this study, we show that ASCs localize to IBC tumor emboli and can be used as a targeted delivery vehicle for cancer nanotherapeutics.